When a toddler knows a word, what does she actually know? Many categories have multiple relevant properties; for example, shape and color are relevant to membership in the category banana. How do toddlers prioritize these properties when recognizing familiar words, and are there systematic differences among children? In this study, toddlers viewed pairs of objects associated with prototypical colors. On some trials, objects were typically colored ; on other trials, colors were switched. On each trial, toddlers were directed to find (...) a target object. Overall, recognition was disrupted when colors were switched, as measured by eye movements. Moreover, individual differences in vocabularies predicted recognition differences: Toddlers who say fewer shape-based words were more disrupted by color switches. “Knowing” a word may not mean the same thing for all toddlers; different toddlers prioritize different facets of familiar objects in their lexical representations. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Rather than focusing on political and legal debates surrounding attempts to determine if and when genocidal rape has taken place in a particular setting, this essay turns instead to a crucial, yet neglected area of inquiry: the moral significance of genocidal rape, and more specifically, the nature of the harms that constitute the culpable wrongdoing that genocidal rape represents. In contrast to standard philosophical accounts, which tend to employ an individualistic framework, this essay offers a situated understanding of harm that (...) features the importance of interdependence and relationality and that conceptualizes harms as embodied and contextual. The paper ultimately reveals what is distinctive about this particular crime of sexual violence by exploring the logic of genocidal rape: genocidal rape involves the harm of forced self-betrayal unleashed relationally, causing victims as representatives of their group to participate inadvertently in the destruction of that group. (shrink)

This review essay engages critically with Heikki Patomäki's The Political Economy of Global Security: War, Future Crises, and Changes in Global Governance. The book is built around the hypothesis that the current ‘era of Neoliberalism’ shares many similarities to the era of the ‘new imperialism’ of the late nineteenth century, ending, catastrophically, in World War I and the Great Depression. Patomäki undertakes this comparison by focusing on the principal long-term historical processes, structures, tendencies and contradictions that may be responsible for (...) the similarities between these two eras. To do so Patomäki constructs an explanatory model of the underlying causal processes and mechanisms involved. The implications are ominous and urgent. The essay uses a close examination of this exemplary case of critical realism in social science to discuss critically its historical explanations, the comparative analysis it makes, and especially the question of agency as theorised in the author's ‘future scenarios’. (shrink)

True enough, not many of the human lot we know, not least of all thosewe may chance upon in life in an intricate tangle of modern socialformations where individuals get to interface rather unreflectively mostof the time, would be so generous as to bestow a casual interest in philosophy. Two thousand years ago, this kind of antipathy toward philosophy made its point well when a man named Socrates was condemned to death, proof rather of the unchanging isometrics of equivocation in (...) the face of the compelling demands of justice and truth that Socrates exposed to be the skeleton in the cupboard of power, hiding under the façade of indestructibility. This pervasive practice would have by now covered an entire époque of Western intellectualtradition from the death of Socrates to the contemporary, disguised asunwavering love of everything that abounds in beauty and vitality, adetermined search for the fundament that holds everything together under the condition that Man is free and that Life is precious as too rich and valuable for the taking. (shrink)

BackgroundEthics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this governance mechanism is still fit for purpose in the data-driven research context remains a debated issue among research ethics experts.Main textIn this article, we seek to address this issue in a twofold manner. First, we review the strengths and weaknesses of ERCs in ensuring ethical oversight. Second, we map (...) these strengths and weaknesses onto specific challenges raised by big data research. We distinguish two categories of potential weakness. The first category concerns persistent weaknesses, i.e., those which are not specific to big data research, but may be exacerbated by it. The second category concerns novel weaknesses, i.e., those which are created by and inherent to big data projects. Within this second category, we further distinguish between purview weaknesses related to the ERC’s scope (e.g., how big data projects may evade ERC review) and functional weaknesses, related to the ERC’s way of operating. Based on this analysis, we propose reforms aimed at improving the oversight capacity of ERCs in the era of big data science.ConclusionsWe believe the oversight mechanism could benefit from these reforms because they will help to overcome data-intensive research challenges and consequently benefit research at large. (shrink)

Imprecise definition of key terms in the “public participation” domain have hindered the conduct of good research and militated against the development and implementation of effective participation practices. In this article, we define key concepts in the domain: public communication, public consultation, and public participation. These concepts are differentiated according to the nature and flow of information between exercise sponsors and participants. According to such an information flow perspective, an exercise’s effectiveness may be ascertained by the efficiency with which full, (...) relevant information is elicited from all appropriate sources, transferred to all appropriate recipients, and combined to give an aggregate/consensual response. Key variables that may theoretically affect effectiveness—and on which engagement mechanisms differ—are identified and used to develop a typology of mechanisms. The resultant typology reveals four communication, six consultation, and four participation mechanism classes. Limitations to the typology are discussed, and future research needs identified. (shrink)

The persistence, and international expansion, of food banks as a non-governmental response to households experiencing food insecurity has been decried as an indicator of unacceptable levels of poverty in the countries in which they operate. In 1998, Poppendieck published a book, Sweet charity: emergency food and the end of entitlement, which has endured as an influential critique of food banks. Sweet charity‘s food bank critique is succinctly synthesized as encompassing seven deadly “ins” (1) inaccessibility, (2) inadequacy, (3) inappropriateness, (4) indignity, (...) (5) inefficiency, (6) insufficiency, and (7) instability. The purpose of this paper is to examine if and how the contemporary food bank critique differs from Sweet charity’s “ins” as a strategy for the formulation of synthesizing arguments for policy advocacy. We used critical interpretive synthesis methodology to identify relationships within and/or between existing critiques in the peer-reviewed literature as a means to create “‘synthetic constructs’ (new constructs generated through synthesis)” of circulating critiques. We analyzed 33 articles on food banks published since Sweet charity, with the “ins” as a starting point for coding. We found that the list of original “ins” related primarily to food bank operations has been consolidated over time. We found additional “ins” that extend the food bank critique beyond operations (ineffectiveness, inequality, institutionalization, invalidation of entitlements, invisibility). No synthetic construct emerged linking the critique of operational challenges facing food banks with one that suggests that food banks may be perpetuating inequity, posing a challenge for mutually supportive policy advocacy. (shrink)

In this paper, we put forward the view that emotions have a legitimate and important role in health professional ethics education. This paper draws upon our experience of running a narrative ethics education programme for ethics educators from a range of healthcare disciplines. It describes the way in which emotions may be elicited in narrative ethics teaching and considers the appropriate role of emotions in ethics education for health professionals. We argue there is a need for a pedagogical framework to (...) productively incorporate the role of emotions in health professional ethics teaching. We suggest a theoretical basis for an ethics pedagogy that integrates health professional emotions in both the experience and the analysis of ethical practice, and identify a range of strategies to support the educator to incorporate emotion within their ethics teaching. (shrink)

There is currently a great debate about whether the holobiont, i.e. a multicellular host and its residential microorganisms, constitutes a biological individual. We propose that resident microorganisms have a general and important role in the individuality of the host organism, not the holobiont. Drawing upon the Equilibrium Model of Immunity, we argue that microorganisms are scaffolds of immune capacities and processes that determine the constituency and persistence of the host organism. A scaffolding perspective accommodates the contingency and heterogeneity of resident (...) microorganisms while accounting for their necessity and unifying contributions to host individuality. In our symbiotic view of life, holobionts may not be organisms or units of selection, but macroorganisms cannot persist nor function as individuals without their scaffolding microorganisms. (shrink)

Pain assessment in fish is particularly challenging due toBioscience Building, Liverpool, L69 7ZB their evolutionary distance from humans, their lack of audible vocalization, and apparently expressionless demeanour. However, there are criteria that can be used to gauge whether pain perception occurs using carefully executed scientific approaches. Here, the standards for pain in fish are discussed and can be considered in three ways: neural detection and processing of pain; adverse responses to pain; and consciously experiencing pain. Many procedures that we subject (...) fish to cause tissue damage and may give rise to the sensation of pain. Fish are popular as pets, in animal exhibits, and as experimental models, but are also cultured or caught for food. There is little legislation for the protection of fish welfare. Many countries are now exploring the welfare cost to fish, and current practices may need to be reviewed with respect to the current evidence for fish perceiving pain. (shrink)

One cue that may facilitate children's word learning is iconicity, or the correspondence between a word's form and meaning. Some have even proposed that iconicity in the early lexicon may serve to help children learn how to learn words, supporting the acquisition of even noniconic, or arbitrary, word–referent associations. However, this proposal remains untested. Here, we investigate the iconicity of caregivers’ speech to young children during a naturalistic free‐play session with novel stimuli and ask whether the iconicity of caregivers’ speech (...) facilitates children's learning of the noniconic novel names of those stimuli. Thirty‐four 1.5‐2‐year‐olds (19 girls; half monolingual English learners and half bilingual English‐Spanish learners) participated in a naturalistic free‐play task with their caregivers followed by a test of word‐referent retention. We found that caregivers’ use of iconicity, particularly in utterances in which they named the novel stimuli, was associated with the likelihood that children learned that novel name. This result held even when controlling for other factors associated with word learning, such as the concreteness and frequency of words in caregiver speech. Together, the results demonstrate that iconicity not only can serve to help children identify the referent of novel words (as in previous research) but can also support their ability to retain even noniconic word‐referent mappings. (shrink)

A wide array of species throughout the animal kingdom has shown the ability to distinguish between quantities. Aside from being important for optimal foraging decisions, this ability seems to also be of great relevance in group-living animals as it allows them to inform their decisions regarding engagement in between-group conflicts based on the size of competing groups. However, it is often unclear whether these animals rely on numerical information alone to make these decisions or whether they employ other cues that (...) may covary with the differences in quantity. In this study we used a touch screen paradigm to investigate the quantity discrimination abilities of two closely related group-living species, wolves and dogs, using a simultaneous visual presentation paradigm. Both species were able to successfully distinguish between stimuli of different quantities up to 32 items and ratios up to 0.80, and their results were in accordance with Weber's law (which predicts worse performances at higher ratios). However, our controls showed that both wolves and dogs may have used continuous, non-numerical cues, such as size and shape of the stimuli, in conjunction with the numerical information to solve this task. In line with this possibility, dogs' performance greatly exceeded that which they had shown in other numerical competence paradigms. We discuss the implications these results may have on these species' underlying biases and numerical capabilities, as well as how our paradigm may have affected the animals' ability to solve the task. (shrink)

Contemporary law and public policy often treat human beings as selfish creatures who respond only to punishments and rewards. Yet every day we behave unselfishly--few of us mug the elderly or steal the paper from our neighbor's yard, and many of us go out of our way to help strangers. We nevertheless overlook our own good behavior and fixate on the bad things people do and how we can stop them. In this pathbreaking book, acclaimed law and economics scholar (...) class='Hi'>Lynn Stout argues that this focus neglects the crucial role our better impulses could play in society. Rather than lean on the power of greed to shape laws and human behavior, Stout contends that we should rely on the force of conscience. Stout makes the compelling case that conscience is neither a rare nor quirky phenomenon, but a vital force woven into our daily lives. Drawing from social psychology, behavioral economics, and evolutionary biology, Stout demonstrates how social cues--instructions from authorities, ideas about others' selfishness and unselfishness, and beliefs about benefits to others--have a powerful role in triggering unselfish behavior. Stout illustrates how our legal system can use these social cues to craft better laws that encourage more unselfish, ethical behavior in many realms, including politics and business. Stout also shows how our current emphasis on self-interest and incentives may have contributed to the catastrophic political missteps and financial scandals of recent memory by encouraging corrupt and selfish actions, and undermining society's collective moral compass. This book proves that if we care about effective laws and civilized society, the powers of conscience are simply too important for us to ignore. (shrink)

This paper aims to offer conceptual clarification on the use of the concept of human flourishing with regard to children. We will argue that the concept can meaningfully be applied to parts of human lives, specifically one's childhood, and discuss when we can meaningfully speak of a flourishing child. Viewing children's lives in terms of whether they are flourishing may be able to help us understand and articulate in which ways a child's life may go better or worse. This is (...) relevant, firstly, to the overall evaluation of people's lives, and secondly, because a flourishing childhood could be instrumentally necessary for adult flourishing. But, most importantly, childhood is a period of life that is good in itself irrespective of its contribution to adult flourishing, that is, being able to be a child has intrinsic goodness. Children have particular characteristics that can optimally function in childhood. While these contribute to the overall evaluation of a flourishing life, they are not regarded as valuable only because of this contribution. (shrink)

International organisations are actors capable of bearing moral responsibilities and ought to be accountable for their failures in doing so. However, we should understand these responsibilities and respond to their failures in the light of fuller considerations about morality and the common good. The article argues that the international community should ensure victims are attended to, but also that defaulting institutions may themselves need rehabilitation for different kinds of international common purposes to be achievable. Further, the ways in which both (...) goals are agreed and undertaken must recognise multiple perspectives, else the possibilities for durable peaceable cooperation internationally will be damaged. Even in a world of plural views, we can find sufficient proximity on matters of ‘good’ and ‘bad’ to move toward further agreement. Drawing on Braithwaite, Rawls, and Sunstein, the article argues we should search out and build on such ‘islands of agreement’ on wrongs in international life and on mutually respectful ways of responding to them. (shrink)

As destructive narcissists attain positions of power, unethical behavior ensues. Organizational identity shifts in response. As a result, unethical decisions become amplified in organizational structure and practices and embedded in technology. Little research related to how employees respond to organizational events, cost/benefit analysis of such, or the effects of negative treatment of employees by organizations is available. As persons become aware of the circumstances generated by destructive narcissistic behavior and informed about the consequences, some will resist. In this article, we (...) provide a model illustrating factors that may give rise to such organizational resistance to destructive arrogant narcissism. (shrink)

This article discusses practice-near research in human services, a cluster of methodologies that may include thick description, intensive reflexivity, and the study of emotional and relational processes. Such methods aim to get as near as possible to experiences at the relational interface between institutions and the practice field. Psychoanalytically informed approaches to research are particularly fruitful here. In this article these are discussed in relation to the reflective practice and critical reflection traditions which have been widely discussed within social work, (...) healthcare, education, and allied fields. Drawing on Clifford Geertz's distinction between experience-near and experience-distant inquiry, this article also discusses the relationship between practice-near and practice-distant approaches. These may be used in parallel to investigate different but related objects of interest and can be used to triangulate different data when focussing on the same object; finally practice-near and practice-distant methods can be combined in interpretive procedures which depend on an oscillation between immersion within and distancing from the field. It is within such interpretive activity that habits of attention and interpretation developed in clinical settings, and described in the work of Wilfred Bion, can be brought to bear usefully on data analysis. (shrink)

There is a lack of published evidence which demonstrates the impacts of public engagement in science and technology policy. This might represent the failure of PE to achieve policy impacts or indicate a lack of effective procedures for discerning the uptake by policy makers of PE-derived outputs. While efforts have been made to identify and categorize different types of policy impact, research has rarely attempted to link policy impact with PE procedures, political procedures, or the connections between them. In this (...) article, we propose a simple conceptual model to capture this information, based on semistructured interviews with both policy makers and PE practitioners. A range of criteria are identified to increase the policy impact of PE. The role of PE practitioners in realizing impacts through their interactions with policy makers in the informal “in-between” spaces of public engagement is emphasized. However, the potential contradictions between the pursuit of policy impacts and the more traditional conceptualizations of PE effectiveness are discussed. The main barrier to the identification of policy impacts from PE may lie within policy processes themselves. Political institutions have responsibility to establish formalized procedures for monitoring the uptake and use of evidence from PE in their decision-making processes. (shrink)

Some commentators have recently proposed that “clinical equipoise,” although widely accepted, is not necessary for morally acceptable research on human subjects. If this concept is rejected, however, we may find that trials not in the best medical interests of their subjects—”bad deal trials”—could be justified. To avoid exploiting participants, we must find a way to distribute the risks fairly, even if it means embracing radical changes in the way clinical research is conducted.

This paper examines, on the basis of a longitudinal corpus of 50 early modern authors, how change at the aggregate level of the community interacts with variation and change at the micro-level of the individual language user. In doing so, this study aims to address the methodological gap between collective change and entrenchment, that is, the gap between language as a social phenomenon and the cognitive processes responsible for the continuous reorganization of linguistic knowledge in individual speakers. Taking up the (...) case of the prepositional passive, this study documents a strong community-wide increase in use that is accompanied by increasing schematicity. A comparison of the 50 authors reveals that regularities arising at the macro-level conceal highly complex and variable individual behavior, aspects of which may be explained by studying the larger (social) context in which these individuals operate (e. g., age cohorts, community of practice, biographical insights). Further analysis, focusing on how authors use the prepositional passive in unique and similar ways, elucidates the role of small individual biases in long-term change. Overall, it is demonstrated that language change is an emergent phenomenon that results from the complex interaction between individual speakers, who themselves may change their linguistic behavior to varying degrees. (shrink)

This article describes the innovative job performance strategies used by women who work as guards in men's prisons. It suggests that women guards perform the job differently from men guards not only because women face structural and discriminatory barriers on the job but also because most women bring to the job a set of prior experiences, skills, and abilities different from those of most men. One of the reasons women may fail to receive positive performance evaluations in jobs traditionally held (...) by men is that they are being evaluated on the basis of how well their work behavior matches that of men doing the same work. This article argues that there are multiple ways to perform jobs and that to expect women to perform jobs in the same manner as their male colleagues is a form of gender bias. Women should be judged by how effective they are, not by whether their approaches to work are similar to those of men. (shrink)

Arguments about temporal becoming often get nowhere. One reason for the impasse lies in the fact that the issue has been formulated as a choice between science on the one hand and common sense (or ordinary language) on the other as the primary source of ontological commitment.' Often' proponents of attributing temporal becoming to the physical universe look to everyday temporal concepts, find them infested with notions involving temporal becoming and conclude that becoming is a basic feature of the physical (...) world. Their opponents may look to physical science, find no reference to temporal becoming and conclude that becoming is not part of the extramental universe.2 Thus construed, the issue of temporal becoming is not directly amenable to argument. This stalemate will be broken, however, if I accomplish my aim: to (re)formulate the question of temporal becoming so that it is subject to adjudication; to show how objections to the thesis of the mind-dependence of becoming can fruitfully be seen (and in a sense unified) as attacks on a single argument for the thesis, an argument from physics; and to defend the con'elusion of the argument from physics from heretofore unanswered objections. The question of the status of temporal becoming is the question of the status of past, present and future.' Events which are at one time in the future, are said to become present and subsequently to recede into the past. Since past and future can be defined as 'earlier than now' and 'later than.. (shrink)

Recent empirical work on the concept of intentionality suggests that people’s assessments of whether an action is intentional are subject to uncertainty. Some researchers have gone so far as to claim that different people employ different concepts of intentional action. These possibilities have motivated a good deal of work in the relatively new field of experimental philosophy. The findings from this empirical research may prove to be relevant to medical ethics. In this article, we address this issue head on. We (...) first describe a study we conducted on intention ascription. Drawing on recent work in experimental philosophy, we investigated the possibility that the ascription of intentions to clinical actors in clinical settings is influenced by prior judgments about the goodness or badness of the consequences of the action in question. Our study was modeled on experimental studies in other contexts that have shown that people, when presented with a range of scenarios, are more likely to classify a side effect of an action as intended if the side effect is negative or reflects poorly on the actor than if it is positive or reflects well on the actor. We investigated whether this asymmetry in intention ascriptions was also present among physicians who were asked to ascribe intentions to clinical actors in certain well-defined clinical scenarios. After describing the study and its results, we discuss its implications for medical ethics. (shrink)

The University of Pittsburgh Medical Center (UPMC) "Policy for the Management of Terminally Ill Patients Who May Become Organ Donors after Death" proposes to take organs from certain patients as soon as possible after expected cardiopulmonary death. This policy requires clear understanding of the descriptive state of the donor's critical cardiopulmonary and neurologic functional capacity at the time interventions to sustain or harvest organs are undertaken. It also requires strong consensus about the moral and legal status of the donor during (...) dying and confirmation of death. There has been no need for the clarity and precision that this policy relies upon, and thus the needed research and conceptual work has not previously been generated. The empiric base and societal consensus are both too frail to provide justification for this policy at this time. (shrink)

The discovery of the first intracellular substrate for insulin, IRS‐1, redirected the field of diabetes research and has led to many important advances in our understanding of insulin action. Detailed analysis of IRS‐1 demonstrates structure/function relationships for this modular docking molecule, including mechanisms of substrate recognition and signal propagation. Recent work has also identified other structurally similar molecules, including IRS‐2, the Drosophila protein, DOS, and the Grb2‐binding protein, Gab1, suggesting that this intracellular signalling strategy is conserved evolutionarily and is utilized (...) by an expanding number of receptor systems. In fact, IRS‐1 itself has been shown to be important in other growth factor and cytokine signalling systems, including growth hormone and several interleukins. Analysis of mice lacking IRS‐1 confirms an important physiological role for this protein in glucose metabolism and general cell growth in the intact animal. Disregulation of the signalling pathways integrated by the IRS proteins may contribute to the pathophysiology of non‐insulin‐dependent diabetes mellitus or other diseases. (shrink)

The matrix‐degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones. It is suggested that the coordinated regulation of matrix metalloproteinases and their inhibitors by these agents modify the integrity of the extracellular matrix. These modifications may, at least in part, be responsible for mediating the effects of these (...) factors on complex physiological processes. (shrink)

For a long time, linguists more or less denied the existence of individual differences in grammatical knowledge. While recent years have seen an explosion of research on individual differences, most usage-based research has failed to address this issue and has remained reluctant to study the synergy between individual and community grammars. This paper focuses on individual differences in linguistic knowledge and processing, and examines how these differences can be integrated into a more comprehensive constructionist theory of grammar. The examination is (...) guided by the various challenges and opportunities that may be extracted from scattered research that exists across disciplines touching on these matters, while also presenting some new data that illustrate how differentiation between individuals can improve models of long-term language change. The paper also serves as the introduction to this special issue of Cognitive Linguistics, which collects seven contributions from various linguistic disciplines focusing on key aspects of individuals’ grammars. (shrink)

This study explores gender differences in approaches to studying for GCSE among high?achieving pupils. The sample comprised 310 Year 10 and 11 pupils from two single?sex schools. Pupils completed a self?reported questionnaire designed to assess approaches to studying for GCSE, including statements relating to coursework, examinations, research, study strategies and homework. Boys gained a higher score overall in the questionnaire, indicating a more effective approach to studying for GCSE. Gender differences were found in approaches to examinations and study but not (...) in approaches to coursework. The boys reported doing less homework than the girls. The findings suggest that overall high?achieving boys have better studying strategies than high?achieving girls. They achieve high standards while doing less homework. Approaches to studying among highachieving girls may be mediated by anxiety that manifests itself in surface approaches to studying for examinations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:MORE THAN METAPHORS: MASCULINEGENDERED NAMES AND THE KNOWABILITY OF GOD LYNNE C. BOUGHTON Chicago, Illinois W:HAT WAS ONCE a phenomenon confined to advocacy groups has appeared in ordinary Catholic parishes. Priests celebrating liturgies offer blessings "In the name of the Creator, the Redeemer, and the Holy Love." Such invocations of Persons of the Trinity by names indicative of divine action, as well as the " naming " of God (...) with either gender-combined (Mother-Father) or gender-neutral (Friend) designations of personal relationships, suggest that the way in which God is addressed need not be different from the way in which one describes divine actions. Many argue that since one may refer to God's specific act as " Creator," characterize God's eternal and temporal activity as " Love," or note that in certain ways people experience God's care as that of a "Friend" or "Mother," these terms are suitable for addressing a divine Person. In early 1992 the Catholic Church's International Commission on English in the Liturgy endorsed non-gendered invocations by proposing that English language liturgical texts delete all masculine pronouns referring to God and replace "Father" in several prayers with gender-neutral names. Willingness to depart from the Father/Son/Holy Spirit terminology found in scripture and the Church's creedal statements is often grounded in the belief that God does not merely excel beyond human comprehension the fatherhood and sonship traditionally attributed to divine Persons, but rather that God, as transcendent being, is essentially unlike any quality that can be named. Those who define transcendence in this " epistemologi283 284 LYNNE C. BOUGHTON cal" way maintain that God is free of definition or distinction and that Persons of the Trinity negate and contradict, in their acts of existence, any permanent identity that the human mind may have " attributed " in scripture or Church doctrine to divine Personhood. Theologians such as Karl Rahner and David Tracy see no departure from the Church's authoritative theological teachings in their definition of transcendence as God's existential freedom from the limitations of eternally existing attributes of Persons. According to Rahner the names most indicative of who God is as God are " ineffable one," " nameless one," " silent one." For Tracy, the central " metaphor " and " doctrine" of Christianity is a " triune understanding" of the words " God is Love." 1 For theologians who define transcendence as God's being unconfined by categories, names by which divine Persons are addressed in Scripture are merely ways in which inspired communities or individuals likened God's dealings with them to lifeaffirming actions or admired personal qualities. If traditional names for God were " revealed" in this way, modern worshippers could reasonably address God in terms of likenesses to other, more 1 Karl Rahner, Foundations of Christian Faith: An Introduction to the Idea of Christianity, tr. William Dych (NY: Crossroad, 1982), pp. 46-71; David Tracy, "The Hermeneutics of Naming God," The Irish Theological Quarterly, 57 (1991) : 253-264. For an analysis and defense of the concept of transcendence as absence of metaphysical reality see Mark I. Wallace, "Can God Be Named Without Being Known?: The Problem of Revelation in Thiemann, Ogden, and Ricoeur," Journal of the American Academy of Religion 59/2 (1991): 281-308. Although the Fourth Lateran Council (1215) listed "ineffable " among the attributes of God, God was not named in this way and, moreover, the context of other listed attributes (omnipotence, eternity) suggests that " ineffable " does not mean God is without anything that can be described but that descriptions of God are not comprehensible to humans [H. J. D. Denzinger, Enchiridion Symbolorum, 30th ed., trans. Roy Deferrari (London: Herder & Herder, 1955), # 428]. This point is illustrated by the First Vatican Council (1869-1870) which refers to God as "ineffably most high above all things " and then proceeds to list a series of attributes (Denzinger, # 1782). In the Council of Toledo, "ineffable" was used as a modifier ("ineffable Trinity," "ineffable substance," "ineffably begot") for terms that were defined in the Council's creed (Denzinger # 275-276). Further discussion of " ineffable" is in note 6, below. MORE THAN METAPHORS 285 inclusive, human qualities. Invoking, rather than merely describing or praising, God with names derived from creative/redemptive... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:MORE THAN METAPHORS: MASCULINEGENDERED NAMES AND THE KNOWABILITY OF GOD LYNNE C. BOUGHTON Chicago, Illinois W:HAT WAS ONCE a phenomenon confined to advocacy groups has appeared in ordinary Catholic parishes. Priests celebrating liturgies offer blessings "In the name of the Creator, the Redeemer, and the Holy Love." Such invocations of Persons of the Trinity by names indicative of divine action, as well as the " naming " of God (...) with either gender-combined (Mother-Father) or gender-neutral (Friend) designations of personal relationships, suggest that the way in which God is addressed need not be different from the way in which one describes divine actions. Many argue that since one may refer to God's specific act as " Creator," characterize God's eternal and temporal activity as " Love," or note that in certain ways people experience God's care as that of a "Friend" or "Mother," these terms are suitable for addressing a divine Person. In early 1992 the Catholic Church's International Commission on English in the Liturgy endorsed non-gendered invocations by proposing that English language liturgical texts delete all masculine pronouns referring to God and replace "Father" in several prayers with gender-neutral names. Willingness to depart from the Father/Son/Holy Spirit terminology found in scripture and the Church's creedal statements is often grounded in the belief that God does not merely excel beyond human comprehension the fatherhood and sonship traditionally attributed to divine Persons, but rather that God, as transcendent being, is essentially unlike any quality that can be named. Those who define transcendence in this " epistemologi283 284 LYNNE C. BOUGHTON cal" way maintain that God is free of definition or distinction and that Persons of the Trinity negate and contradict, in their acts of existence, any permanent identity that the human mind may have " attributed " in scripture or Church doctrine to divine Personhood. Theologians such as Karl Rahner and David Tracy see no departure from the Church's authoritative theological teachings in their definition of transcendence as God's existential freedom from the limitations of eternally existing attributes of Persons. According to Rahner the names most indicative of who God is as God are " ineffable one," " nameless one," " silent one." For Tracy, the central " metaphor " and " doctrine" of Christianity is a " triune understanding" of the words " God is Love." 1 For theologians who define transcendence as God's being unconfined by categories, names by which divine Persons are addressed in Scripture are merely ways in which inspired communities or individuals likened God's dealings with them to lifeaffirming actions or admired personal qualities. If traditional names for God were " revealed" in this way, modern worshippers could reasonably address God in terms of likenesses to other, more 1 Karl Rahner, Foundations of Christian Faith: An Introduction to the Idea of Christianity, tr. William Dych (NY: Crossroad, 1982), pp. 46-71; David Tracy, "The Hermeneutics of Naming God," The Irish Theological Quarterly, 57 (1991) : 253-264. For an analysis and defense of the concept of transcendence as absence of metaphysical reality see Mark I. Wallace, "Can God Be Named Without Being Known?: The Problem of Revelation in Thiemann, Ogden, and Ricoeur," Journal of the American Academy of Religion 59/2 (1991): 281-308. Although the Fourth Lateran Council (1215) listed "ineffable " among the attributes of God, God was not named in this way and, moreover, the context of other listed attributes (omnipotence, eternity) suggests that " ineffable " does not mean God is without anything that can be described but that descriptions of God are not comprehensible to humans [H. J. D. Denzinger, Enchiridion Symbolorum, 30th ed., trans. Roy Deferrari (London: Herder & Herder, 1955), # 428]. This point is illustrated by the First Vatican Council (1869-1870) which refers to God as "ineffably most high above all things " and then proceeds to list a series of attributes (Denzinger, # 1782). In the Council of Toledo, "ineffable" was used as a modifier ("ineffable Trinity," "ineffable substance," "ineffably begot") for terms that were defined in the Council's creed (Denzinger # 275-276). Further discussion of " ineffable" is in note 6, below. MORE THAN METAPHORS 285 inclusive, human qualities. Invoking, rather than merely describing or praising, God with names derived from creative/redemptive... (shrink)

: "Clinical pragmatism" is an important new method of moral problem solving in clinical practice. This method draws on the pragmatic philosophy of John Dewey and recommends an experimental approach to solving moral problems in clinical practice. Although the method may shed some light on how clinicians and their patients ought to interact when moral problems are at hand, it nonetheless is deficient in a number of respects. Clinical pragmatism fails to explain adequately how moral problems can be solved experimentally, (...) it underestimates the relevance and importance of judgment in clinical ethics, and it presents a questionable account of the role that moral principles should play in moral problem solving. (shrink)

Purpose Recent research has found unrealistic optimism among patient-subjects in early-phase oncology trials. Our aim was to investigate the cognitive and motivational factors that evoke this bias in this context. We expected perceptions of control to be a strong correlate of unrealistic optimism. Methods A study of patient-subjects enrolled in early-phase oncology trials was conducted at two sites in the USA. Respondents completed questionnaires designed to assess unrealistic optimism and several risk attribute variables that have been found to evoke the (...) bias in other contexts. Results One hundred and seventy-one patient-subjects agreed to be interviewed for our study. Significant levels of perceived controllability were found with respect to all nine research-related questions. Perceptions of control were found to predict unrealistic optimism. Two other risk attribute variables, awareness of indicators and mental image, were correlated with unrealistic optimism. However, in multivariate regression analysis, awareness and mental image dropped out of the model and perceived controllability was the only factor independently associated with unrealistic optimism. Conclusion Patient-subjects reported that they can, at least partially, control the benefits they receive from participating in an early-phase oncology trial. This sense of control may underlie unrealistic optimism about benefiting personally from trial participation. Effective interventions to counteract unrealistic optimism may need to address the psychological factors that give rise to distorted risk/benefit processing. (shrink)

: Some commentators have recently proposed that "clinical equipoise," although widely accepted, is not necessary for morally acceptable research on human subjects. If this concept is rejected, however, we may find that trials not in the best medical interests of their subjects--bad deal trials--could be justified. To avoid exploiting participants, we must find a way to distribute the risks fairly, even if it means embracing radical changes in the way clinical research is conducted.

Any artefact – a hammer, a telescope, an artificial hip – may malfunction. Conceptually speaking, artefacts have an inherent normative aspect. I argue that the normativity of artefacts should be understood as part of reality, and not just “in our concepts.” I first set out Deflationary Views of artefacts, according to which there are no artefactual properties, just artefactual concepts. According to my contrasting view – the Constitution View – there are artefactual properties that things in the world really have. (...) For example, there is a property of being a telephone per se; we apply our concept telephone to things that have that property. Things that have the property of being a telephone are constituted by, but not identical to, aggregates of particles. To be an artefact, an object must have an intended function, among other things. Telephones – in virtue of being the kind of objects that they are – are always subject to malfunction. And malfunctions, when they occur, are just as much part of the world as telephones are. The example of artefacts shows that what is in the world – what really exists – need not be “mind-independent” nor independent of our concepts. (shrink)

The mouse t-complex, located on chromosome 17, contains genes known to influence male, but not female, fertility. Although some t-complex genes are recessive lethals, t-chromosomes are maintained in the population by transmission ratio distortion. When male mice heterozygous for the t-chromosome mate with wild-type females, most offspring will possess the t-chromosome, indicating a link between t-complex genes and sperm function. Several proteins coded for by t-complex genes have been localised in the sperm flagellum, suggesting roles relating to motility. Another t-complex (...) protein appears able to regulate the adenylyl cyclase/cAMP signal transduction pathway, known to play an important role in capacitation. Defective motility and/or failure to capacitate (“switch on”) would result in poorly fertile or infertile spermatozoa. Given the existence of human homologues for many genes in the t-complex and the prevalence of “male factor” infertility, information obtained about the t-complex not only will provide insight into basic biological mechanisms but may be of future clinical relevance as well. BioEssays 21:304–312, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

Within emotion-focused therapy, the client’s ability to express and reflect on core emotional experiences is seen as fundamental to constructing the self and to entering into a change process. For this study, we 1) examine storytelling contexts in which clients do not disclose the emotional impact of their narrative, and 2) identify the interactional practices through which EFT therapists subsequently call attention to what the client may have felt. In doing so, we examine client stories drawn from video-taped individual psychotherapy (...) sessions involving clinically depressed clients. Client stories and therapists’ responses to these stories were analysed using conversation analytic methods. Three different therapist response types were identified: eliciting, naming and illustrating the emotional impact of the client’s prior narrative. These responses also were found to differ in terms of how effectively they could display empathy and secure affiliation with clients. The implications of this work for therapeutic practice are discussed. (shrink)

“Form follows function,” the slogan of modernist architecture, could well be a slogan of artefacts generally. Since the choice of material for a tool is guided by the function of the tool, we may be tempted to think that having a functional nature distinguishes artefacts from natural objects. But that would be a mistake. Certain natural objects—especially biological entities like mammalian hearts—have functional natures too.

The Plant Ontology (PO) is a community resource consisting of standardized terms, definitions, and logical relations describing plant structures and development stages, augmented by a large database of annotations from genomic and phenomic studies. This paper describes the structure of the ontology and the design principles we used in constructing PO terms for plant development stages. It also provides details of the methodology and rationale behind our revision and expansion of the PO to cover development stages for all plants, particularly (...) the land plants (bryophytes through angiosperms). As a case study to illustrate the general approach, we examine variation in gene expression across embryo development stages in Arabidopsis and maize, demonstrating how the PO can be used to compare patterns of expression across stages and in developmentally different species. Although many genes appear to be active throughout embryo development, we identified a small set of uniquely expressed genes for each stage of embryo development and also between the two species. Evaluating the different sets of genes expressed during embryo development in Arabidopsis or maize may inform future studies of the divergent developmental pathways observed in monocotyledonous versus dicotyledonous species. The PO and its annotation databasemake plant data for any species more discoverable and accessible through common formats, thus providing support for applications in plant pathology, image analysis, and comparative development and evolution. (shrink)

Ask any of your single female friends — and some of your married ones — about men, and they will likely complain that the men they meet avoid commitment like rats avoid electric shock. Although the therapists of these women may say that they choose men who avoid commitment, a recent television show on being single in America treated millions of viewers to scenarios one hears women repeat a thousand times: a man comes onto a woman like she's water in (...) the desert, smothers her in the first few weeks with flowers, balloon-o-grams, phone calls, and professions of love, says he's never felt so wonderful with a woman in his over-thirty life, and then, as quickly and suddenly as he came on, he disappears. (shrink)

The use of virtual environments for the provision of health‐care is on the increase, and with each new development brings debates about their impact on care, nursing and nursing practice. Such environments offer opportunities for extending care and improvements in communication. Others believe these developments threaten aspects of nursing they hold sacrosanct. This paper explores the development of an assemblage of computer networks, databases, information systems, software programs and management systems that together work to manage health‐care in Australia, namely casemix. (...) We contend that spatial theories on network society show how this assemblage co‐ordinates and operates to manage care. We discuss how this assemblage affects care and suggest that changes in organisation may be a part of the shift in how bodily organisation occurs more generally, but more specifically in health‐care. We also suggest how nurses are enrolled in and by such networks, leading to transformation in nurses’ practices. Finally, we argue that using spatial forms of analysis allows an interpretation of such assemblages that may account for their strengths and their shortcomings. (shrink)

Dewey emphasizes the perception of “indirect consequences” of transactions as the basis of responsible public identity and organization. These consequences are external; they appear in the scientifically observable world and are susceptible to technical control. But transactions may have indirect affective consequences that are part of a culturally influenced inner reality, pose obstacles to speech and communication, and fund an irresponsible public identity-cum-organization. Rhetorical theory that builds on Dewey's “public” ignores these consequences at considerable cost. This claim is supported by (...) a social psychoanalytic conception of affects and by an interpretive-analysis of public speech-acts that moved from opposition to the largely unauthorized immigration of Latin Americans to Nashville-Davidson County, Tennessee, to reactionary endorsement and legislative passage of an “English-first” ordinance. (shrink)

Theories of spatial cognition are derived from many sources. Psychologists are concerned with determining the features of the mind which, in combination with external inputs, produce our spatialized experience. A review of philosophical and other approaches has convinced us that the brain must come equipped to impose a three-dimensional Euclidean framework on experience – our analysis suggests that object re-identification may require such a framework. We identify this absolute, nonegocentric, spatial framework with a specific neural system centered in the hippocampus.A (...) consideration of the kinds of behaviours in which such a spatial mapping system would be important is followed by an analysis of the anatomy and physiology of this system, with special emphasis on the place-coded neurons recorded in the hippocampus of freely moving rats. A tentative physiological model for the hippocampal cognitive map is proposed. A review of lesion studies, in tasks as diverse as discrimination learning, avoidance, and extinction, shows that the cognitive map notion can adequately explain much of the data.The model is extended to humans by the assumption that spatial maps are built in one hemisphere, semantic maps in the other. The latter provide a semantic deep structure within which discourse comprehension and production can be achieved. Evidence from the study of amnesic patients, briefly reviewed, is consistent with this extension. (shrink)

This commentary suggests that the physical substrate of integrated information is dependent on the reference frame used to observe it. Furthermore, it uses a thought experiment – can a neuroscientist, locked in a closed room and connected through Zoom with his grandmother to demonstrate that the consciousness of his grannie is NOT in the PC? – to underline the problems that neglecting reference frames may cause to consciousness research.

When healthcare professionals feel constrained from acting in a patient’s best interests, moral distress ensues. The resulting negative sequelae of burnout, poor retention rates, and ultimately poor patient care are well recognized across healthcare providers. Yet an appreciation of how particular disciplines, including physicians, come to be “constrained” in their actions is still lacking. This paper will examine how the application of shared decision-making may contribute to the experience of moral distress for physicians and why such distress may go under-recognized. (...) Appreciation of these dynamics may assist in cross-discipline sensitivity, enabling more constructive dialogue and collaboration. (shrink)

Aeschylus' account of the sacrifice of Iphigeneia in theAgamemnonhas elicited an extraordinarily wide range of interpretations–a critical response which, in its veryproductivity, may signal a central aspect of the description itself. While more recent explications have been profitably informed by research in cult and ritual, there remains, I would like to suggest, an important literary possibility which merits consideration, particularly in a text where so much has been shaped from a close and profound engagement with the Homeric tradition. The description (...) of the sacrifice is forcefully carried by enjambement from one stanza into another by the sheer weight, as it were, of the force that crushingly silences, βίαι χαλινὦν τ᾿ άναύδωι μ⋯νει. In the midst of much that is dark and difficult to construe, the composition yields a sudden effusion of colour, a striking trail of saffron. The sense of concealment, of a figure enveloped or enshrouded, which has been suggested by the phrase πέπλοισι περιπετή, opens on to an image of unfolding, the falling spread of a robe caught in itsflow towards the ground, κρόκου βαφάς δ ⋯ς πέδονχέουσα. (shrink)

In this paper, I consider the question of whether there is such a thing as ‘expertise in research ethics’. I discuss first the issue of expertise in ethics more generally. There is quite a lot of resistance to the idea that there are ethics experts, for reasons which I will raise and respond to. I outline two different views of what might be counted as expertise in ethics, and argue that only one of these is defensible. But the defensible view (...) is also a useful view. Ethics expertise in this sense does exist. It is a set of generic analytic skills and knowledge of ideas and logical processes. Expertise in research ethics is a particular type of ethics expertise, and I give a brief account of what it includes, and how it differs from ethics expertise in general. I end with the suggestion that people with such expertise would be useful members of Human Research Ethics Committees, and steps ought to be taken to increase the likelihood that they become members. This may or may involve adding the category of ‘ethicist’ to the list of HREC membership categories. (shrink)